People
PI
Faculty
Postdoctoral Fellows
Students
Lab Staff
Secretary
Principal Investigator: Maode Lai

MD, Professor and Chairman
Department of Pathology and Pathophysiology
School of Medicine, Zhejiang University
Hangzhou, 310058, P. R. China
Phone(Office): 86-571-88208200
Phone(Lab): 86-571-88208197
Fax: 86-571-88208198
E-mail: lmd@zju.edu.cn
Education
  • M.D. in Pathology, Luebeck Medical University, Germany
  • M.S. in Pathology, Zhejiang Medical University, China
  • B. A. in Clinical Medicine, Zhejiang Medical University, China
Position Held
Research Interests
  • Pathology of Colorectal Cancer
  • Cancer Genomics
  • Cancer Protenomics
Professional Experience
  • 1998.9-present
 Professor and Chairman of Pathology department and vice-president, Zhejiang University, Hangzhou, China
  • 1996-1998
 Professor of pathology and vice-president, Zhejiang Medical University, Hangzhou, China
  • 1994-1995
 Professor of pathology and Dean of Basic Medical Sciences, Zhejiang Medical University, Hangzhou, China
  • 1990-1994
 Lecturer and associate professor, Zhejiang Medical University, Hangzhou, China
  • 1987-1989
 Lecturer, Department of pathology, Zhejiang Medical University, Hangzhou, China
  • 1983-1984
 Assistant, Zhejiang Medical University, Hangzhou, China
Selected Publications
  • Ye, F., et al., Decreased expression of insulin-like growth factor binding protein 7 in human colorectal carcinoma is related to DNA methylation. J Cancer Res Clin Oncol, 2007. 133(5): p. 305-14.
  • Xu, E., et al., Association of matrix metalloproteinase-2 and -9 promoter polymorphisms with colorectal cancer in Chinese. Mol Carcinog, 2007.
  • Ruan, W., et al., IGFBP7 Plays a Potential Tumor Suppressor Role in Colorectal Carcinogenesis. Cancer Biol Ther, 2007. 6(3): p. 354-9.
  • Lu, B., et al., Systemic analysis of the differential gene expression profile in a colonic adenoma-normal SSH library. Clin Chim Acta, 2007. 378(1-2): p. 42-7.
  • Lin, J., et al., Methylation patterns of IGFBP7 in colon cancer cell lines are associated with levels of gene expression. J Pathol, 2007. 212(1): p. 83-90.
  • Zhu, Y.M., et al., Expression of human DNA methyltransferase 1 in colorectal cancer tissues and their corresponding distant normal tissues. Int J Colorectal Dis, 2006.
  • Zhu, Y., et al., Genotypes, haplotypes, and diplotypes of XPC and risk of bladder cancer. Carcinogenesis, 2006.
  • Xu, E., et al., No association between the polymorphisms in matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter regions and colorectal cancer in Chinese. Dis Colon Rectum, 2006. 49(9): p. 1439-44.
  • Xing, X., et al., Overexpression of glucose-regulated protein 78 in colon cancer. Clin Chim Acta, 2006. 364(1-2): p. 308-15.
  • Xing, X., et al., Identification of differentially expressed proteins in colorectal cancer by proteomics: down-regulation of secretagogin. Proteomics, 2006. 6(9): p. 2916-23.
  • Wang, G.F., et al., Histological types and significance of bronchial epithelial dysplasia. Mod Pathol, 2006. 19(3): p. 429-37.
  • Ruan, W.J., et al., IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1. J Zhejiang Univ Sci B, 2006. 7(11): p. 929-32.
  • Ruan, W.J., M.D. Lai, and J.G. Zhou, Anticancer effects of Chinese herbal medicine, science or myth? J Zhejiang Univ Sci B, 2006. 7(12): p. 1006-14.
  • Lai, M., et al., Secretagogin, a novel neuroendocrine marker, has a distinct expression pattern from chromogranin A. Virchows Arch, 2006. 449(4): p. 402-9.
  • Cui, J., et al., Identification of a novel VNTR polymorphism in C6orf37 and its association with colorectal cancer risk in Chinese population. Clin Chim Acta, 2006. 368(1-2): p. 155-9.
  • Xu, E., et al., DHPLC analysis of the matrix metalloproteinase-1 promoter 1G/2G polymorphism that can be easily used to screen large population. J Biochem Biophys Methods, 2005. 63(3): p. 222-7.
  • Lu, B.J., M.D. Lai, and M. Dietel, An overview of the Sino-German symposium on new developments in surgical and basic pathology. Virchows Arch, 2005. 446(5): p. 569-76.
  • Cheng, L., et al., Enhanced fusion of myoblasts with myofibers for efficient gene delivery induced by a partially purified protein fraction from rat muscle extract. Arch Biochem Biophys, 2005. 441(2): p. 141-50.
  • Xu, E., et al., A single nucleotide polymorphism in the matrix metalloproteinase-2 promoter is associated with colorectal cancer. Biochem Biophys Res Commun, 2004. 324(3): p. 999-1003.
  • Shao, L., et al., Detection of the differentially expressed gene IGF-binding protein-related protein-1 and analysis of its relationship to fasting glucose in Chinese colorectal cancer patients. Endocr Relat Cancer, 2004. 11(1): p. 141-8.
  • Ruan, W.J. and M.D. Lai, Autocrine stimulation in colorectal carcinoma (CRC): positive autocrine loops in human colorectal carcinoma and applicable significance of blocking the loops. Med Oncol, 2004. 21(1): p. 1-8.
  • Lu, B.J., et al., Gastric medullary carcinoma, a distinct entity associated with microsatellite instability-H, prominent intraepithelial lymphocytes and improved prognosis. Histopathology, 2004. 45(5): p. 485-92.
  • Zhang, Y.W., L.S. Ding, and M.D. Lai, Reg gene family and human diseases. World J Gastroenterol, 2003. 9(12): p. 2635-41.
  • Zhang, Y., et al., Overexpression of Reg IV in colorectal adenoma. Cancer Lett, 2003. 200(1): p. 69-76.
  • Zhang, Y., et al., Reg IV, a differentially expressed gene in colorectal adenoma. Chin Med J (Engl), 2003. 116(6): p. 918-22.
  • Lai, M.D., Y.M. Zhu, and X.M. Gu, [Severe acute respiratory syndrome]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2003. 32(3): p. 167-70.
  • Cheng, L. and M.D. Lai, Aberrant crypt foci as microscopic precursors of colorectal cancer. World J Gastroenterol, 2003. 9(12): p. 2642-9.
  • Chen, X.X., et al., Less cytotoxicity to combination therapy of 5-fluorouracil and cisplatin than 5-fluorouracil alone in human colon cancer cell lines. World J Gastroenterol, 2002. 8(5): p. 841-6.
  • Chen, X., M.D. Lai, and Q. Huang, Increased sensitivity of colorectal cancer cell lines with microsatellite instability to 5-fluorouracil in vitro. Chin Med J (Engl), 2002. 115(7): p. 1048-52.
Honors
  • Zhejiang Province of China science and technology improvement award，2005，2004，1998
  • Ministry of health P.R. China science and technology improvement award, 1988
Memberships and Offices in Professional Societies
  • Chinese Medical Association Pathology Branch (vice chairman)
  • Zhejiang Medical Association (vice chairman)
  • Zhejiang Medical Association Pathology Branch ( chairman)
  • Zhejiang Sino- German Medical Association (director)
  • Chinese anti-cancer Association Pathology Branch (member)
Editorial Boards
  • Chinese Journal of Pathology ( editorial board)
  • World Chinese Journal of Digestion ( associate editor)
  • Chinese Journal of Clinical and Experimental Pathology (executive associate editor)
  • Foreign Medical Sciences (section of genetics) ( editorial board)
  • Journal of Zhejiang University (medical sciences) ( editor-in Chief)
  • Journal of Practical Oncology (executive associate editor)
  • Zhejiang Medical Journal ( editorial board)
  • Acta Genetica Sinica ( editorial board)
  • Hereditas ( editorial board)
Copyright©2006-2011
PO Box 19, School of Medicine, Zhejiang University, Hangzhou, 310058, P.R. China